• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Deep intracervical insemination device in swine. It comprises a catheter whose anterior end is coupled to the cervix of the animal by means of an adhered piece present in the anterior part thereof; inside the catheter runs a cannula of smaller diameter and extends beyond that and at the front end of which there is a stopper with a rounded finish to avoid injury to the mucosa of the sow and which has at least one hole frontal exit of the semen, allowing the deposit of this in the most cranial part of the cervix. The opposite end of the cannula is designed to be coupled to the back of the catheter and thus prevent fluid loss during insemination and retraction of the cannula. The device, with preferential application in nulliparous sows, allows to optimize the conditions of artificial insemination. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2600378A1
    申请号:ES201600600
    申请日:2016-07-12
    公开日:2017-02-08
    发明作者:Francisco Alberto GARCIA VÁZQUEZ；Pedro José LLAMAS LÓPEZ
    申请人:Universidad de Murcia；
    IPC主号:
    专利说明:

    DESCRIPTION

    Deep intracervical insemination device in pigs.

    Object of the invention 5

    The object of the present invention is to provide a simple and easy-to-use device for introducing semen at the deep cervical level in sows, extending said deposit to the cranial area of the cervix of the animal's uterus, thereby reaching greater depth than traditional cervical insemination. , and reducing spermatic losses 10 by reflux through the device during insemination, thanks to the manual coupling that occurs between the cannula and the catheter on the back of the device. All this allows to use a smaller amount of semen in each insemination obtaining similar or better productive yields with respect to traditional techniques. This device, due to its design and dimensions, is of special application in young sows, especially nulliparous, since the use of post-cervical or intrauterine insemination in this type of animals is very limited, or practically null, and therefore It presents an alternative to traditional cervical insemination.

    Technical sector 20

    The present invention falls within the field of veterinary medicine devices, in particular in the field of instruments for reproduction or fertilization by artificial insemination in pig farming.
     25
    Background of the invention and state of the art

    In the last two decades, assisted reproduction technologies have increased exponentially due to the development of new biotechnological applications in both the human and animal species. Artificial insemination (AI) is included among these methods. Although this technique is not as new as others, it is still considered one of the most revolutionary techniques applied in farm animals. AI can be defined as an assisted reproduction method where sperm are artificially deposited in the female's genital tract in order to fertilize it. Today, more than 90% of the sows are artificially inseminated 35 in the European Union and North America, reaching 98% in certain countries. AI has great advantages over natural mounts, such as genetic improvements due to the use of high-value males, lower health risk, economic savings, ease of handling, seminal quality control, etc.
     40
    The main objective during an AI, as well as the natural mountain, is that an adequate population of sperm reach the fertilization site during the peri-ovulatory period. During a natural mountain, a large volume of seminal fluid (~ 200-500 ml) and number of sperm (~ 20,000-70,000 x106) are deposited in the female's genital tract. Four. Five

    AI at the cervical level has been the most widely used insemination technique in swine species worldwide. This technique is simple to perform in field conditions and basically consists in the deposition of semen in the most cranial area of the cervix of the animal's uterus through the use of a catheter, simulating the natural conditions that would occur during a natural ride. Through this technique the females are
    inseminated with 3,000x106 sperm in a volume of 80-100 ml, obtaining fertility results of about 90% and between 10-14 total piglets born.

    But in the last two decades, new AI strategies have been developed with the idea of depositing the semen closer to the fertilization site than cervical AI would, thus reducing the volume and number of sperm. One of these techniques is called post-cervical AI or intrauterine insemination, which involves the deposition of semen in the body of the uterus, just after the cervix and before the bifurcation of the uterine horns. Post-cervical AI is performed 10 by combining a catheter (such as those used in cervical AI) and a cannula that runs through the inside of the catheter and allows the semen to deposit 16-20 cm deeper in what cervical AI would do.

    Experimental studies of the application of post-cervical AI at the farm level have confirmed that they offer better results with respect to the application of cervical AI, reducing semen deposited in half (1,500x106 sperm / 40 ml) or one third (1,000x106 sperm / 26 ml) of the one used in cervical AI (3,000x106 sperm / 80 ml).
     twenty
    Therefore, there are several advantages of this new type of AI compared to traditional techniques, such as economic savings by increasing the number of sows that can be inseminated with a single male, having fewer numbers of boars on the farm, final product more homogeneous, time saving in the application of AI, etc.
     25
    The main problem of post-cervical AI is that its application is not possible, or is very limited, in young sows such as nulliparous sows, that is, in sows that have entered fertile age but have not had offspring. This type of females is the base of the farms and supposes on average more than 20% of the population of breeding females in a pig farm. 30

    Studies conducted applying post-cervical AI in nulliparous sows are very limited, and with mixed results. Studies show that the use of post-cervical AI is not as effective as in multiparous sows, since only 23% of nulliparous sows could be inseminated with current commercial post-35 cervical AI catheters used in multiparous sows.

    The main limitation found in the application of post-cervical insemination in nulliparous sows is the difficulty in inserting the insemination catheter, especially in the deepest part (cranial part) of the cervix, being much more difficult than in sows 40 multiparous It has been shown that erasing the cervix during labor induces changes in the connective matrix of the cervix, so that its wall becomes more loose and distensible. This reason, together with the poor development of the nulliparous sows' reproductive system, prevents the post-cervical AI system from being applied to this type of sows with guarantees. Four. Five

    The present invention offers a solution to this problem through a new AI device whose main novelty is that it is designed based on the morphology and specific dimensions of the nulliparous sow reproductive system that allows semen deposition not in the post-cervical region, after the cervix, due to its anatomical impossibility to cross it, but in the deep cervical region, that is, the
    anterior part of the cervix. In addition, this device prevents the loss of seminal fluids through the catheter during insemination, thus maximizing performance. For all this, this device considerably increases the success rate of the current application of post-cervical AI in nulliparous women, obtaining similar or even better fertility and prolificacy results than the use of conventional cervical AI. It is a device of simple application and easy use at farm level and although it is an instrument designed primarily for application in nulliparous sows, its use can also be extended to the rest of sows (primiparous and multiparous).

    Description of the invention 10

    The present invention relates to a device that allows semen to be deposited in the cranial part of the cervix of a sow and that allows deep intracervical insemination thereof, while preventing the loss of sperm fluid through the device during insemination. fifteen

    This device comes to fulfill the objective of achieving a deeper insemination compared to that achieved with traditional cervical insemination in those sows where intrauterine insemination cannot be applied (mostly nulliparous sows). For this, this device allows the deposition of semen in the cranial part 20 of the cervix of the sow's uterus, thereby reducing the number of sperm to deposit with respect to conventional cervical insemination, obtaining similar productive results or better than traditional cervical insemination systems.
     25
    The invention is constituted by a standard cervical insemination catheter of tubular and hollow shape, made of flexible materials, preferably plastic, in which its front end, used for its introduction in the sow reproductive apparatus, has an attached piece, which it can have a diverse morphology although preferably spiral or concentric and successive rings, which allows its fixation to the cervix of the sow due to the anatomical characteristics of the sow, while its posterior end ends in a thickening that acts as a handle and that facilitates its clamping. The object of the invention is determined by the inside of the catheter axially runs a hollow cannula no larger than 50 cm or longer than 59.9 cm long and not less than 1.5 mm thick and not larger than 3.49 35 mm , based on the anatomical characteristics of the nulliparous sow. This cannula is made of flexible materials, and is smaller in diameter than the catheter that receives it, being designed to allow semen deposition at a deep intracervical level, specifically in the cranial part of the cervix.
     40
    This cannula passes through the inside of the catheter and emerges at its anterior end through part of the cervix until it reaches the point of semen deposit. The cannula is topped at its front end in a rounded cap, which can have a spherical or cylindrical shape, of a diameter slightly greater than or equal to the diameter of the cannula and less than or equal to the internal diameter of the tubular body of the catheter and consists of a hole 45 front that allows the exit and deposit of semen. Alternatively, the plug may have a variable number of holes of equal or smaller size than the front hole indicated above and which may be arranged laterally or frontally of said plug. On the other hand, the back of the cannula has a hole that serves as a connection between the inside of the cannula and the outside to adapt the 50 cans or bags that contain the semen for insemination. At that end it
    It finds a piece, which can take a conical or cylindrical shape, which covers the final part of the cannula and which in turn can be coupled, by manual pressure, to the back of the catheter, preventing fluid loss and retraction of the cannula outward.
     5
    In those problematic sows in which the entrance of the cannula through the cervix is difficult, a flexible, preferably metallic, and non-traumatic guide can be used that runs axially through the inside of the cannula and exits through the front hole of the same, facilitating the search of the entrance hole of the cervix to subsequently insert the cannula successfully. Once the cannula is correctly positioned by means of the guide, it will be removed for the subsequent deposition of the semen.

    The semen is introduced through the axial cavity of the inner cannula until its exit through the rounded anterior end being deposited at the level of the anterior part of the cervix. The described features of the deep intracervical insemination device referred to the invention allow semen to be deposited in the depth of the cervix, ensuring optimal productive results with the use of 1,500 x 06 sperm, and even smaller amounts, which means a considerable reduction of the amount of semen usually used in traditional cervical insemination (3,000x1 06). In addition, the fact of inseminating in greater depth through the new insemination device object of the invention results in a lower loss of the sperm dose introduced due to reflux through the vulva, since the volume (%) and concentration Sperm (%) collected in reflux are lower through the use of the device of the invention than with the use of traditional cervical insemination. It also prevents the loss of fluids, and consequently sperm, through the back of the cervical catheter during insemination because the conical part that covers the back of the cannula allows its adjustment to the back of the catheter.

    Description of the figures 30

    FIG. 1. Representation in side elevation of the artificial insemination device.

    FIG. 2. Elevation representation of the artificial insemination device and the fluid inlet orifice through the cannula. 35

    FIG. 3. View of the cross section of the device assembly.

    FIG. 4. General view of the device with the flexible guide that runs through the inside of the cannula. 40

    FIG. 5. View of the cross section of the device assembly in its coupling between the catheter and the cannula at its rear.

    FIG. 6. Detailed and enlarged view of the rounded end end of the cannula. Four. Five

    FIG. 7. Schematic view of the cross section of the reproductive tract of a sow with the catheter / cannula assembly inserted in the genital tract of the animal.

    FIG. 8. View of another alternative embodiment of an internal cannula with the cap 50 rounded from the front end with different outlet channels.
    Reference List

    1. Tubular catheter.

    2. Piece attached to the anterior part of the catheter that allows its attachment to the cervix of the 5 sow.

    3. External thickening of the back of the catheter.

    4. Cannula. 10

    5. Rounded cap of the anterior end of the cannula.

    6. Front hole of the rounded plug.
     fifteen
    7. Hole to receive the coupling of bags or semen dose bottles.

    8. Conical shaped part of the back of the cannula.

    9. Flexible guide that runs through the inside of the cannula. twenty

    10. Coupling of the cannula-catheter device on its back.

    11. Back of the cervix of the sow reproductive system where semen is deposited. 25

    12. Side holes of the rounded cap of the anterior end of the cannula.

    Description of a preferred embodiment of the invention
     30
    The insemination device described in the present invention is represented by a tubular catheter 1 of appropriate length and diameter, terminated with frontal openings at its ends. The anterior part of said catheter incorporates an adhered piece 2 with morphology in the form of concentric and successive rings that allows its fixation to the cervix of the bristle, while its rear end ends in a thickening 3 that acts as a handle and that facilitates its subjection by the person who manipulates it.

    From this structure and in accordance with the present invention, a hollow cannula 4 with a length longer and 40 diameter smaller than that of the catheter runs axially inside the tubular catheter, allowing it to reach deeper into the interior of the tube. genital tract of the female. The anterior end of the cannula ends in a spherical cap 5 that has a diameter equal to or greater than the tubular part of the inner cannula and less than or equal to the internal diameter of the tubular body of the catheter, which is suitable for moving along of the cervix without eroding or damaging your mucosa. This plug has a hole 6 in its front part for the exit and discharge of the semen, in the cranial area of the cervix of the sow of the sow to inseminate, communicating the outer part with the inside. The spherical plug in which the cannula ends may have different channels or outlet holes with different diameters 12, which may be frontal and / or lateral to the cannula. fifty
    The cannula is inserted into the catheter through which it runs until it reaches the cervix of the female. The rear end of the cannula is prepared with a hole 7 to receive the coupling of bags or semen dose cans. A conical shaped part 8 is attached to the back of the cannula which in turn allows its adjustment in the back of the catheter 10 to prevent retraction and displacement of the cannula, as well as the loss of seminal fluid through the catheter during insemination. In the case of difficulty in introducing the cannula through the cervix, the device is provided with a flexible metal guide 9 that runs through the inside of the cannula and which facilitates the search for the entrance hole of the cervix to subsequently introduce the cannula with success.
     10
    In figure 7 it can be seen how the end of the cannula reaches the cranial part of the cervix where the fluid or semen would be deposited 11.
    权利要求:
    Claims (13)
    [1]

    1. Device for artificial intracervical insemination in pig farming, which is intended to introduce sperm into the cranial area of the cervix of the animal's uterus (11), which comprises a tubular catheter (1) whose posterior end includes a thickening 5 constituting a handle of subjection (3) and in whose anterior part it presents an adhered piece (2) that facilitates its introduction and fixation at the entrance of the cervical canal; characterized in that a hollow cannula (4) is provided inside the catheter (1), emerging through the anterior end of said catheter; said cannula (4) ends at its front end in the form of a rounded plug (5) of diameter equal to or slightly greater than the diameter of the cannula (4) and having a hole at the frontal level (6) for semen exit, while its rear end has a piece (8) that covers the final part of said cannula and which in turn is coupled to the back of the catheter (1).

    [2]
    2. Device of artificial insemination intracervical in pig farming, according to claim 1, characterized in that the cannula (4) has a length greater than the set that determines the tubular catheter (1), and the subsequent thickening of it (3), being said length sufficient for the cannula (4) at its maximum introduction into the swine female to be able to reach the cranial area of the cervix (11).
     twenty
    [3]
    3. Device for artificial intracervical insemination in pig farming, according to previous claims, characterized in that the cannula (4) has at its rear end a hole (7) suitable for receiving the bags or cans containing the semen to be inoculated.
     25
    [4]
    4. Device for artificial intracervical insemination in pig farming, according to previous claims, characterized in that the length of the cannula (4) is less than 59.9 cm and greater than 50 cm.

    [5]
    5. Device for artificial intracervical insemination in pig farming, according to 30 previous claims, characterized in that the diameter of the cannula (4) is less than 3.49 mm and greater than 1.5 mm.

    [6]
    6. Device for artificial intracervical insemination in pig farming, according to previous claims, characterized in that a guide (9) runs through the inside of the cannula (4) that facilitates the passage of the cannula (4) through the cervical canal and that is removed at the time of semen deposition.

    [7]
    7. Device for artificial intracervical insemination in pig farming, according to claim 6, characterized in that the guide (9) is made of any type of flexible material.

    [8]
    8. Device for artificial intracervical insemination in pig farming, according to claim 1, characterized in that the rounded cap (5) has a cylindrical shape.
     Four. Five
    [9]
    9. Device for artificial intracervical insemination in pig farming, according to claim 1, characterized in that the rounded plug (5) has a conical shape.

    [10]
    10. Device for artificial intracervical insemination in pig farming, according to 50 claims 1, 8 and 9, characterized in that the rounded plug (5) has a
    variable number of holes arranged at the front or side level (12) for semen output.

    [11]
    11. Intracervical artificial insemination device in pig farming, according to claim 10, characterized in that the holes arranged at the frontal or lateral level 5
    (12) have a variable diameter.

    [12]
    12. Device for artificial intracervical insemination in pig farming, according to claim 1, characterized in that the part (8) present at the rear end of the cannula (4) and which is coupled to the back of the tubular catheter (1) has a conical shape . 10

    [13]
    13. Intracervical artificial insemination device in pig farming, according to claim 1, characterized in that the part (8) present at the rear end of the cannula (4) and which is coupled to the back of the tubular catheter (1) has a cylindrical shape .
     fifteen

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    同族专利:
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    ES2600378B1|2017-11-17|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US5674178A|1996-06-12|1997-10-07|Root; Robert W.|Artificial insemination tool|
    WO2001049205A1|2000-01-03|2001-07-12|Iberica De Reproduccion Asistida, S.L.|Artificial insemination device for pigs|
    WO2001052767A1|2000-01-20|2001-07-26|Universidad De Murcia|Device and method for introducing and/or collecting fluids from he interior of the uterus of an animal|
    ES2247318T3|2001-06-14|2006-03-01|Minitube Of America, Inc.|INTRA-UTERINE INSEMINATION DEVICE FOR PIGS AND EMBRYO TRANSPLANT.|
    US20120078036A1|2009-06-05|2012-03-29|Ecopor|Probe for artificial insemination, in particular for pigs|
    法律状态:
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